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2014

2013

Association between mammographic breast density and lifestyle in Japanese women.

Ishihara S, Taira N, Kawasaki K, Ishibe Y, Mizoo T, Shien T, Doihara H, Kanazawa S .

Acta Med Okayama. 67:145-51. 2013

p53 expression in pretreatment specimen predicts response to neoadjuvant chemotherapy including anthracycline and taxane in patients with primary breast cancer.

Shien T, Kinoshita T, Seki K,Yoshida M,Hojo T,Shimizu C,Taira N, Doihara H,Tanaka S, Tsuda H,Fujiwara Y

Acta Med Okayama. 67:167-170. 2013

Breast cancer subtype and distant recurrence after ipsilateral breast tumor recurrence.

Ishitobi M, Okumura Y, Arima N, Yoshida A, Nakatsukasa K, Iwase T, Shien T, Masuda N, Tanaka S, Tanabe M, Tanaka T, Komoike Y, Taguchi T, Nishimura R, Inaji H.

Ann Surg Oncol. 20:1886-92. 2013

Effects of lifestyle and single nucleotide polymorphisms on breast cancer risk: a case-control study in Japanese women. 

Mizoo T, Taira N, Nishiyama K, Nogami T, Iwamoto T, Motoki T, Shien T, Matsuoka J, Doihara H, Ishihara S, Kawai H, Kawasaki K, Ishibe Y, Ogasawara Y, Komoike Y, Miyoshi S. 

BMC Cancer. 13,565. 2013

Women prefer adjuvant endocrine therapy to chemotherapy for breast cancer treatment.

Niikura N, Kimura M, Iwamoto T, Hayashi N, Shintoku J, Saito Y, Suzuki Y, Tokuda Y.

Breast Cancer. 20:67-74. 2013

Repeat lumpectomy for ipsilateral breast tumor recurrence (IBTR) after breast0conserving surgery: the impact of radiotherapy on second IBTR.

Ishitobi M, Okumura Y, Nishimura R, Nakatsukasa K, Tanabe M, Yoshida A, Masuda N, Shien T, Tanaka S, Komoike Y, Arima N, Taguchi T, Inaji H; Collaborative StudyGroup of Scientific Research of the Japanese Breast Cancer Society.

Breast Cancer. 21:754-60. 2013

Proliferation and estrogen signaling can distinguish patients at risk for early versus late relapse among estrogen receptor positive breast cancers.

Bianchini G, Pusztai L, Karn T, Iwamoto T, Rody A, Kelly CM, Muller V, Schmidt M, Qi Y, Holtrich U, Becker S, Santarpia L, Fasolo A, Del Conte G, Zambetti M, Sotiriou C, Haibe-Kains B, Symmans WF, Gianni L.

Breast Cancer Res. 15:R86. 2013

Comparison of molecular subtype distribution in triple-negative inflammatory and non-inflammatory breast cancers.

Masuda H, Baggerly KA, Wang Y, Iwamoto T, Brewer T, Pusztai L, Kai K, Kogawa T, Finetti P, Birnbaum D, Dirix L, Woodward WA, Reuben JM, Krishnamurthy S, Symmans WF, Van Laere SJ, Bertucci F, Hortobagyi GN, Ueno NT.

Breast Cancer Res. 15:R112. 2013

A 3-gene proliferation score (TOP-FOX-67) can re-classify histological grade-2, ER-positive breast cancers into low- and high-risk prognostic categories.

Szekely B, Iwamoto T, Szasz AM, Qi Y, Matsuoka J, Symmans WF, Tokes AM, Kulka J, Swanton C, Pusztai L.

Breast Cancer Res Treat. 138:691-8. 2013

Estrogen receptor (ER) mRNA expression and molecular subtype distribution in ER-negative/progesterone receptor-positive breast cancers.

Itoh M, Iwamoto T, Matsuoka J, Nogami T, Motoki T, Shien T, Taira N, Niikura N, Hayashi N, Ohtani S, Higaki K, Fujiwara T, Doihara H, Symmans WF, Pusztai L.

Breast Cancer Res Treat. 143:403-9. 2013

Clinical benefit from neoadjuvant chemotherapy in oestrogen receptor-positive invasive ductal and lobular carcinomas.

Delpech Y, Coutant C, Hsu L, Barranger E, Iwamoto T, Barcenas CH, Hortobagyi GN, Rouzier R, Esteva FJ, Pusztai L.

Br J Cancer. 108:285-91. 2013

Statin use in primary inflammatory breast cancer: a cohort study.

Brewer TM, Masuda H, Liu DD, Shen Y, Liu P, Iwamoto T, Kai K, Barnett CM, Woodward WA, Reuben JM, Yang P, Hortobagyi GN, Ueno NT.

Br J Cancer. 109:318-24. 2013

TIG1 Promotes the Development and Progression of Inflammatory Breast Cancer through Activation of Axl Kinase.

Wang X, Saso H, Iwamoto T, Xia W, Gong Y, Pusztai L, Woodward WA, Reuben JM, Warner SL, Bearss DJ, Hortobagyi GN, Hung MC, Ueno NT.

Cancer Res. 73:6516-25. 2013

Uncovering the molecular secrets of inflammatory breast cancer biology: an integrated analysis of three distinct affymetrix gene expression datasets.

Van Laere SJ, Ueno NT, Finetti P, Vermeulen P, Lucci A, Robertson FM, Marsan M, Iwamoto T, Krishnamurthy S, Masuda H, van Dam P, Woodward WA, Viens P, Cristofanilli M, Birnbaum D, Dirix L, Reuben JM, Bertucci F.

Clin Cancer Res. 19:4685-96. 2013

DNA repair gene patterns as prognostic and predictive factors in molecular breast cancer subtypes.

Santarpia L, Iwamoto T, Di Leo A, Hayashi N, Bottai G, Stampfer M, Andre F, Turner NC, Symmans WF, Hortobagyi GN, Pusztai L, Bianchini G.

Oncologist. 18:1063-73. 2013

Bayesian Mixture Models for Assessment of Gene Differential Behaviour and Prediction of pCR through the Integration of Copy Number and Gene Expression Data.

Trentini F, Ji Y, Iwamoto T, Qi Y, Pusztai L, Muller P.

PLoS One. 8:e68071. 2013

乳癌と分子標的薬

土井原博義

岡山医学会雑誌 125:243-50. 2013

StageⅣ乳癌に対する原発巣切除の意義について

枝園忠彦,土井原博義

Bressance 14-15. 2013

がん手術療法の変遷・ 発展と手術患者QOL~乳がん手術療法を中心に~

土井原博義

がん看護 19:106-110. 2013

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論文

p53 expression in pretreatment specimen predicts response to neoadjuvant chemotherapy including anthracycline and taxane in patients with primary breast cancer.

Shien T, Kinoshita T, Seki K, Yoshida M, Hojo T, Shimizu C, Taira N, Doihara H, Akashi-Tanaka S, Tsuda H, Fujiwara Y.

Acta Med Okayama. 67:165-70. 2014

Gene expression profiles of inflammatory breast cancer: correlation with response to neoadjuvant chemotherapy and metastasis-free survival.

Bertucci F, Ueno NT, Finetti P, Vermeulen P, Lucci A, Robertson FM, Marsan M, Iwamoto T, Krishnamurthy S, Masuda H, Van Dam P, Woodward WA, Cristofanilli M, Reuben JM, Dirix L, Viens P, Symmans WF, Birnbaum D, Van Laere SJ.

Ann Oncol 25:358-65. 2014

Long-term treatment efficacy in primary inflammatory breast cancer by hormonal receptor- and HER2-defined subtypes

Masuda H, Brewer TM, Liu DD, Iwamoto T, Shen Y, Hsu L, Willey JS, Gonzalez-Angulo AM, Chavez-MacGregor M, Fouad TM, Woodward WA, Reuben JM, Valero V, Alvarez RH, Hortobagyi GN, Ueno NT.

Ann Oncol 25:384-91. 2014

Expression of ALDH1 in axillary lymph node metastases is a prognostic factor of poor clinical outcome in breast cancer patients with 1-3 lymph node metastases. Breast Cancer.

"Nogami T, Shien T, Tanaka T, Nishiyama K, Mizoo T, Iwamto T, Ikeda H, Taira N, Doihara H, Miyoshi S."

Breast Cancer. 21:58-65. 2014

Breast biopsy for mammographically detected nonpalpable lesions using a vacuum-assisted biopsy device (Mammotome) and upright-type stereotactic mammography unit without a digital imaging system: experience of 500 biopsies.

Ohsumi S, Taira N, Takabatake D, Takashima S, Hara F, Takahashi M, Kiyoto S, Aogi K, Nishimura R.

Breast Cancer 21:123-7. 2014

Impact of preservation of the intercostobrachial nerve during axillary dissection on sensory change and health-related quality of life 2 years after breast cancer surgery.

Taira N, Shimozuma K, Ohsumi S, Kuroi K, Shiroiwa T, Watanabe T, Saito M.

Breast Cancer 21:183-90. 2014

Clinicopathological features of young patients (<35 years of age) with breast cancer in a Japanese Breast Cancer Society supported study.

Kataoka A, Tokunaga E, Masuda N, Shien T, Kawabata K, Miyashita M.

Breast Cancer. 21:643-50. 2014

Fertility preservation in breast cancer patients.

Shien T, Nakatsuka M, Doihara H.

Breast Cancer 21:651-5. 2014

The discordance between primary breast cancer lesions and pulmonary metastatic lesions in expression of aldehyde dehydrogenase1-positive cancer cells.

"Nogami T, Shien T, Tanaka T, Doihara H, Taira N, Takabatake D, Nishimura R, Nishiyama K, Mizoo T, Ohsumi S. "

Breast Cancer. 21:698-702. 2014

Assessment of the Ki67 labeling index: a Japanese validation ring study

Niikura N, Sakatani T, Arima N, Ohi Y, Honma N, Kanomata N, Yoshida K, Kadoya T, Tamaki K, Kumaki N, Iwamoto T, Sugie T, Moriya T. Assessment of the Ki67 labeling index: a Japanese validation ring study

Breast Cancer

Health-related quality of life and psychological distress during neoadjuvant endocrine therapy with letrozole to determine endocrine responsiveness in postmenopausal breast cancer.

Taira N, Iwata H, Hasegawa Y, Sakai T, Higaki K, Kihara K, Yamaguchi T, Ohsumi S, Shimozuma K, Ohashi Y.

Breast Cancer Res Treat 145:155-64. 2014

Safety analysis of two different regimens of uracil-tegafur plus leucovorin as adjuvant chemotherapy for high-risk stage II and III colon cancer in a phase III trial comparing 6 with 18 months of treatment: JFMC33-0502 trial.

Tsuchiya T, Sadahiro S, Sasaki K, Kondo K, Katsumata K, Nishimura G, Kakeji Y, Baba H, Morita T, Koda K, Sato S, Matsuoka J, Yamaguchi Y, Usuki H, Hamada C, Kodaira S, Saji S.

Cancer Chemother Pharmacol. 73:1253-61.2014

Prognostic significance of the ki67 scoring categories in breast cancer subgroups. Clin Breast Cancer

Niikura N, Masuda S, Kumaki N, Xiaoyan T, Terada M, Terao M, Iwamoto T, Oshitanai R, Morioka T, Tuda B, Okamura T, Saito Y, Suzuki Y, Tokuda Y.

Clin Breast Cancer 14:323-9 e3. 2014

Tamoxifen versus tamoxifen plus doxorubicin and cyclophosphamide as adjuvant therapy for node-positive postmenopausal breast cancer: results of a Japan Clinical Oncology Group Study (JCOG9401).

Shien T, Iwata H, Aogi K, Fukutomi T, Inoue K, Kinoshita T, Takahashi M, Matsui A, Shibata T, Fukuda H.

Int J Clin Oncol. 19:982-8. 2014

Utility of the Singapore nomogram for predicting recurrence-free survival in Japanese women with breast phyllodes tumours.

Nishimura R, Tan PH, Thike AA, Tan MH, Taira N, Li HH, Ohsumi S.

J Clin Pathol 67:748-50. 2014

Fertility concerns and preservation strategies in young women with breast cancer.

Shien T.

J Thorac Dis. 6:581-3. 2014

TP53 mutation-correlated genes predict the risk of tumor relapse and identify MPS1 as a potential therapeutic kinase in TP53-mutated breast cancers.

Gyorffy B, Bottai G, Lehmann-Che J, Keri G, Orfi L, Iwamoto T, Desmedt C, Bianchini G, Turner NC, de The H, Andre F, Sotiriou C, Hortobagyi GN, Di Leo A, Pusztai L, Santarpia L.

Mol Oncol 8:508-19. 2014

Ink4a/Arf(-/-) and HRAS(G12V) transform mouse mammary cells into triple-negative breast cancer containing tumorigenic CD49f(-) quiescent cells

Kai K, Iwamoto T, Kobayashi T, Arima Y, Takamoto Y, Ohnishi N, Bartholomeusz C, Horii R, Akiyama F, Hortobagyi GN, Pusztai L, Saya H, Ueno NT

Oncogene 33:440-8. 2014

Resection of the primary tumor in stage IV breast cancer.

Shien T, Doihara H.

World J Clin Oncol. 5:82-5. 2014

転移診断の検討

土井原博義 

岡山医学会雑誌 126:25-30. 2014

早期乳癌におけるOne-step Nucleic Acid Amplification(OSNA)法によるセンチネルリンパ節 乳がん診療の質の向上を目指して

溝尾妙子,枝園忠彦,伊藤麻衣子,野上智弘,岩本高行,元木崇之,平成人,松岡順治,土井原 博義.

岡山医学会雑誌 126: 25-30. 2014

乳がん検診の現状

土井原博義

岡山県医師会報 1385:34-36. 2014

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2015

Neoadjuvant Chemotherapy with or without Concurrent Hormone Therapy in Estrogen Receptor-Positive Breast Cancer:NACED-Randomized Multicenter Phase II Trial

Sugiu K, Iwamoto T, Kelly CM, Watanabe N, Motoki T, Ito M, Ohtani S, Higaki K, Imada T, Yuasa T, Omori M, Sonobe H, Fujiwara T, Matsuoka J. 

Acta Med Okayama. 69:291-9

Correlation between 18F-fluorodeoxyglucose Positron Emission Tomography/computed Tomography and Clinicopathological Features in Invasive Ductal Carcinoma of the Breast.

Ito M, Shien T, Kaji M, Mizoo T, Iwamoto T, Nogami T, Motoki T, Taira N, Doihara H, Miyoshi S.

Acta Med Okayama. 69:338-8

Changes in Tumor Expression of HER2 and Hormone Receptors Status after Neoadjuvant Chemotherapy in 21,755 Patients from the Japanese Breast Cancer Registry

Niikura N, Tomotaki A, Miyata H, Iwamoto T, Kawai M, Anan K, Hayashi N, Aogi K, Ishida T, Masuoka H, Iijima K, Masuda S, Tsugawa K, Kinoshita T, Nakamura S, Tokuda Y.

Ann Oncol. 27(3):480-8

The Japanese Breast Cancer Society clinical practice guideline for epidemiology and prevention of breast cancer.

Taira N, Arai M, Ikeda M, Iwasaki M, Okamura H, Takamatsu K, Yamamoto S, Ohsumi S, Mukai H; Japanese Breast Cancer Society.

Breast Cancer. 22: 16-27

Evaluation of aldehyde dehydrogenase 1 and transcription factors in both primary breast cancer and axillary lymph node metastases as a prognostic factor

Ito M,Shien T,Omori M,Mizoo T,Iwamoto T,Nogami T,Motoki T,Taira N,Doihara H,Miyoshi S

Breast Cancer. 23:437-44

Comprehensive prognostic report of the Japanese Breast Cancer Society registry in 2006

Iwamoto T, Fukui N, Kinoshita T, Anan K, Niikura N, Kawai M, Hayashi N, Tsugawa K, Aogi K, Ishida T, Masuoka H, Masuda S, Iijima K, Nakamura S, Tokuda Y. 

Breast Cancer. Oct 13. Epub ahead of print

Clinicopathological factors predicting early and late distant recurrence in estrogen receptor-positive, HER2-negative breast cancer.

Yamashita H, Ogiya A, Shien T, Horimoto Y, Masuda N, Inao T, Osako T, Takahashi M, Endo Y, Hosoda M, Ishida N, Horii R, Yamazaki K, Miyoshi Y, Yasojima H, Tomioka N; Collaborative Study Group of Scientific Research of the Japanese Breast Cancer Society.

Breast Cancer. Oct. 14 Epub ahead of print

Unmet Information Needs and Quality of Life in Young Breast Cancer Survivors in Japan

Miyashita M,Ohno S,Kataoka A,Tokunaga E,Masuda N,Shien T,Kawabata K,Takahashi M

Cancer Nurs. 38: E1-11

Relative Prognostic and Predictive Value of Gene Signature and Histologic Grade in Estrogen Receptor-Positive, HER2-Negative Breast Cancer

Iwamoto T, Kelly C, Mizoo T, Nogami T, Motoki T, Shien T, Taira N, Hayashi N, Niikura N, Fujiwara T, Doihara H, Matsuoka J. 

Clin Breast Cancer. 16:95-100

Subtype specific metagene-based prediction of outcome after neoadjuvant and adjuvant treatment in breast cancer.

Callari M, Cappelletti V, D'Aiuto F, Musella V, Lembo A, Petel F, Karn T, Iwamoto T, Provero P, Daidone MG, Gianni L, Bianchini G.

Clin Cancer Res. 22: 337-45

 

Change in estrogen receptor, HER2, and Ki-67 status between primary breast cancer and ipsilateral breast cancer tumor recurrence

Okumura Y,Nishimura R,Nakatsukasa K,Yoshida A,Masuda N,Tanabe M,Shien T,Tanaka S,Arima N,Komoike Y,Taguchi T,Iwase T,Inaji H,Ishitobi M

Eur J Surg Oncol. 41:548-552

A model to predict upstaging to invasive carcinoma in patients preoperatively diagnosed with ductal carcinoma in situ of the breast.

Kondo T, Hayashi N, Ohde S, Suzuki K, Yoshida A, Yagata H, Niikura N, Iwamoto T, Kida K, Murai M, Takahashi Y, Tsunoda H, Nakamura S, Yamauchi H.

J Surg Oncol. 112: 476-80

Metastatic Cutaneous Apocrine Adenocarcinoma Treated With a Combination of Pertuzumab-Based Targeted Therapy and Taxane Chemotherapy: A Case Report

Otsuka M,Yamasaki O,Kaji T,Shien T,Iwatsuki K

JAMA Dermatol. 152(1):111-3

Executive Committee for the Setouchi Breast Cancer Cohort Study:Impact of modifiable lifestyle factors on outcomes after breast cancer diagnosis: the Setouchi Breast Cancer Cohort Study

Taira N,Akiyama I,Ishihara S,Ishibe Y,Kawasaki K,Saito M,Shien T,Nomura T,Hara F,Mizoo T,Mizota Y,Yamamoto S,Ohsumi S,Doihara H

Jpn J Clin Oncol. 45:600-2

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2016

Study about the Efficacy of Metformin to Immune Function in Cancer Patients